目的 基于文献检索,对变应性鼻炎与中医体质相关性的数据进行meta分析,以期为临床实践中变应性鼻炎的防治提供有效循证医学依据。方法 通过PubMed,中国知网等数据库筛选文献,使用AHRQ横向研究质量评估量表,以Stata12.0行Meta分析,再进行异质性分析。结果 ①研究共检索到文献266篇,最终共纳入文献11篇,共3848例变应性鼻炎患者样本。②根据Meta分析结果,变应性患者的体质以气虚质[95%CI=0.35(0.23,0.48),P<0.01]、阳虚质[95%CI=0.25(0.17,0.32),P<0.01]、特禀质[95%CI=0.24(0.14,0.35),P<0.01]居多,其中气虚质最为常见。结论 现有的证据表明,气虚质、阳虚质和特禀质是变应性鼻炎患者的主要中医体质类型,气虚、阳虚及遗传特异体质可能是变应性鼻炎患病的危险因素,然而,这个结论还需要更多的高质量,多中心,大样本的RCT实验来证实。

Objective Based on literature search, meta analysis was conducted on the data of the correlation between allergic rhinitis and traditional Chinese medicine constitution, in order to provide effective evidence-based medical basis for the prevention and treatment of allergic rhinitis in clinical practice. Methods Literatures were screened through PubMed, CNKI and other databases. AHRQ cross-sectional study quality assessment scale, Stata12.0 were used for meta-analysis, and then heterogeneity analysis was performed. Results ①A total of 266 articles were retrieved, and 11 articles were included in the final analysis, with 3848 samples from allergic rhinitis patients. ②According to the results of meta-analysis, the constitution of allergic patients consisted of Qi-deficiency quality [95%CI=0.35 (0.23, 0.48), P<0.01], Yang-deficiency quality [95%CI=0.25 (0.17, 0.32), P<0.01], inherited specialties quality [95%CI=0.24 (0.14, 0.35), P<0.01], among which Qi-deficiency was the most common. Conclusions Existing evidence shows that Qi-deficiency, Yang-deficiency and inherited specialties deficiency are the main TCM constitution types of patients with allergic rhinitis, and qi-deficiency, Yang-deficiency and genetic specific constitution may be the risk factors for allergic rhinitis. However, this conclusion needs more high-quality, multi-center, large-sample RCT experiments to confirm.