【摘要】目的 我们进行了一项荟萃分析，以更加确切的阐明STK39与高血压之间的关联。方法 检索来自PubMed、EMBASE、Web of science、the Cochrane Library等数据库的已发表文献，并使用固定或随机效应模型计算95%置信区间（CI）的合并优势比（OR）。结果 采用适当的纳入/排除标准，我们确定了十二项研究，包括来自不同种族的24267名高血压患者和15935名对照。荟萃分析显示STK39 rs3754777 rs35929607 rs6749447变异与高血压无相关关系，相对应的OR值，95%CI和p值分别为：[1.15，（0.91，1.46），0.23]，[0.95,（0.85，1.06），0.37]，[1.18,（0.87，1.61），0.30] 。我们在以种族，实验设计，样本量大小和发表年份为类别对人群进行亚组分析时，显示涉及白种人群的研究（OR=1.37，95%CI=1.16，1.62，p<0.05），设计类型为前瞻性设计的研究(OR=1.36，95%CI=1.01，1.83，p<0.05)，样本量≥1500（OR=1.44，95%CI=1.01，2.06，p<0.05）以及发表年份为2014之前（不包括2014）（OR=1.11，95%CI=1.02，1.22，p<0.05）的研究是有统计学意义的，这些研究说明位点rs3754777与高血压发生相关。我们通过敏感性分析进一步证实了研究结果。未检测到出版偏倚。结论 目前的荟萃分析证实了STK39与高血压不存在显著的相关性，不建议以SPAK激酶的发病机制作为研究高血压的防治措施

【 Abstract 】 Objective We conducted a meta-analysis to clarify the association between STK39 and hypertension. Methods Published literatures from PubMed, EMBASE, Web of science, and the Cochrane Library were retrieved, and combined odds ratios (OR) of 95% confidence intervals (CI) were calculated using fixed or random effects models. Results Using appropriate inclusion/exclusion criteria, we identified twelve studies that included 24,267 patients with hypertension and 15,935 controls from various ethnic groups. Meta-analysis showed no correlation between STK39 rs3754777 rs35929607 rs6749447 and hypertension. The corresponding OR values, 95%CI and p values were: [1.15, (0.91, 1.46), 0.23], [0.95, (0.85, 1.06), 0.37], [1.18, (0.87, 1.61), 0.30. In subgroup analysis of populations by race, experimental design, sample size, and year of publication, we showed that studies involving white populations (OR= 1.37, 95%CI=1.16, 1.62, p=0.0003) and prospective design studies (OR=1.36, 95%CI=1.01, 1.83, p=0.04), sample size ≥1500 (OR=1.44, 95%CI=1.01, 2.06, p=0.04), and publication year prior to 2014 (excluding 2014) (OR=1.11, 95%CI=1.02, 1.22, p=0.02) were statistically significant. These studies indicate that site rs3754777 is associated with hypertension. We further confirmed the results through sensitivity analysis. No publication bias was detected. Conclusions The present meta-analysis confirmed no significant association between STK39 and hypertension, and it is not recommended to study the pathogenesis of SPAK kinase as a preventive measure for hypertension.