心血管疾病(cardiovascular disease,CVD)是导致全球死亡率升高的最大单一因素,其被列为全球重大健康问题。其中载脂蛋白A-I(Apolipoprotein A-I,apo A-I)、载脂蛋白B(Apoprotein B,Apo B)以及Apo B/Apo A-I是CVD的有效预测指标。 在引起CVD的众多原因中,就寝时间是不容忽视的风险因素,长期晚睡易引发失眠、昼夜节律紊乱等一系列睡眠问题,进而通过影响神经递质水平、引发全身慢性炎症反应、影响脂肪酸代谢和血压调节等机制最终促使CVD的发生和发展。因此养成规律、健康的就寝时间对预防CVD至关重要。

Cardiovascular disease (CVD) is the most crucial factor in increasing global mortality, a significant global health problem. Apolipoprotein A-I (apo A-I), Apolipoprotein B (Apo B), and Apo B/Apo A-I were effective predictors of CVD. Among the many causes of CVD, bedtime is a risk factor that cannot be ignored. Long-term late bedtime causes insomnia, circadian rhythm disturbance, and a series of sleep problems, which ultimately promote the occurrence and development of CVD by affecting the level of neurotransmitters, triggering a systemic chronic inflammatory response, affecting fatty acid metabolism and blood pressure regulation, and other mechanisms. Therefore, developing a regular and healthy bedtime is crucial to preventing CVD. This review comprehensively analyzes the pathophysiological mechanism of late bedtime-mediated cardiovascular diseases, such as neurotransmitters and inflammatory factors, which can guide sleep hygiene to prevent the occurrence of cardiovascular diseases.

内蒙古自然科学基金面上项目(2022MS08068)