摘要 目的：探讨影响应用万古霉素患者肾功能的相关因素。方法：回顾分析鄂尔多斯市中心医院2015年1月1日至2021年1月1日收治的使用万古霉素且进行血药浓度监测的143例住院患者临床资料，Logistic分析给药剂量、年龄、血肌酐、血药谷浓度等与肾功能损伤的相关性。结果：143例患者中26例患者用药后出现急性肾损伤，发生率为18.2%。在多变量分析中万古霉素的用药剂量（p=0.005）、血药谷浓度(>20mg/L,p=0.002)、基线血清肌酐水平(p=0.000)是万古霉素血药低谷浓度的独立相关因素。结论:患者使用万古霉素出现肾功能损伤与患者给药剂量、基线血清肌酐、血药谷浓度显著相关，用药时需仔细评估个体化给药。

Abstract Objective: To investigate the related factors that affect the renal function of patients with vancomycin. Methods: A retrospective analysis of the clinical data of 143 inpatients treated with vancomycin and blood concentration monitoring in Ordos Central Hospital from January 1, 2015 to January 1, 2021. Logistic analysis of the dose, age, and blood The correlation between creatinine and blood trough concentration and renal function damage. Results: 26 of the 143 patients developed acute kidney injury after medication, the incidence was 18.2%. In the multivariate analysis, vancomycin dosage (p=0.005), blood concentration (>20mg/L, p=0.002), and baseline serum creatinine level (p=0.000) were independent of the trough vancomycin blood concentration relevant factors. Conclusion: The renal function impairment of patients using vancomycin is significantly related to the patient's dosage, baseline serum creatinine, and blood trough concentration. Careful evaluation of individualized administration is required during medication.