有氧糖酵解途径是肿瘤细胞特征性的代谢方式。多数肿瘤细胞通过提高葡萄糖摄取率、增强糖酵解活性和产生大量乳酸,来促进肿瘤细胞的生长和转移,包括乳腺癌。乳腺癌是女性最常见的肿瘤,也是最主要的肿瘤性死亡原因。乳腺癌大多具有糖酵解活性,其中葡萄糖转运蛋白(GLUT)、单羧酸转运蛋白(MCT)和乳酸脱氢酶(LDH)等糖酵解关键酶表达水平影响乳腺癌的进展,这为改善患者的预后和肿瘤的靶向治疗提供参考。

Aerobic glycolysis is a characteristic metabolic pathway of tumor cells. Most tumor cells promote the growth and metastasis of tumor cells, including breast cancer, by increasing glucose uptake rate, enhancing glycolysis activity and producing large amounts of lactic acid. Breast cancer is the most common tumor in women and the leading cause of tumor death. Most breast cancers have the activity of glycolysis, in which the expression of glucose transporter (GLUT), monocarboxylic acid transporter (MCT), lactate dehydrogenase (LDH) and other key enzymes of glycolysis affect the progression of breast cancer, which provides reference for improving the prognosis of patients and targeted therapy for tumors.